SNP variants in the NME7 gene in the Czech cohort

Given that T2DM is common in several ciliopathies, the <i>NME7</i> gene (non-metastatic cells 7), encoding a recognized member of the ciliome, was included in our panel of genes studied in connection with glucose metabolism and its disorders. Variability in human motile cilia-related genes may represent a connection between cilia motility, islet beta-cell function and disturbances in glucose homeostasis, even T2DM. Several human genetic diseases characterized by disorders of energy metabolism have been linked to primary cilia dysfunction (Bardet-Biedl or Alström syndrome). 1,262 volunteers with varying degrees of glucose tolerance underwent a 3-h OGTT. Glucose curves were categorized into four groups according to their shape: monophasic, biphasic, triphasic and more complex multiphasic. Our aim was to find out whether the response to administered glucose is associated with variability in the <i>NME7</i> gene.