A Chiral Phosphoramidite Reagent for the Synthesis of Inositol Phosphates

There is a paucity
of chiral phosphoramidite reagents or chiral
catalysis methods for the synthesis of biologically relevant inositol
phosphates. A new C2-symmetrical chiral
phosphoramidite has been developed and successfully applied to the
synthesis of a set of chiral inositol bisphosphates. The reagent allowed
bis-phosphorylation and chiral resolution, resulting in a concise
synthetic route, thus expanding the toolbox available for the preparation
of biologically relevant inositol phosphates in high optical purity.