Exploring Proteomic Differences in PBMCs for Sex-Specific Insights into Alzheimer’s Disease

This study investigated sex-dependent proteomic alterations in peripheral blood mononuclear cells (PBMCs) from Alzheimer’s disease (AD) patients. Quantitative DIA-based proteomics revealed both shared and sex-specific pathways, including complement activation, coagulation, and metabolic processes. These findings highlight systemic immune and metabolic remodeling in AD that differ between males and females.