Gene expression in drug resistant and circulating tumor cell cultured H460 or A549 cells Overall design: mRNA expression profiles of 2-dimensionally cultured and circulating tumor cell cultured H460 a
This study identifies phosphorylation of SHP2 at tyrosine 62 (pY62) as a conserved mechanism of resistance to allosteric SHP2 inhibitors. By stabilizing an open, active SHP2 conformation, pY62 phenoco
Tetracyclines (TCs) are an important class of antibiotics threatened by an emerging new resistance mechanismenzymatic inactivation. These TC-inactivating enzymes, also known as tetracycline destructa
