Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide

Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide Descriptor: 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide, Discoidin domain-containing receptor 2 Authors: Stihle, M, Richter, H, Benz, J, Kuhn, B, Rudolph, M.G. Deposit date: 2018-01-03 Release date: 2018-11-28 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.87 Å) Cite: DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome. Acs Chem.Biol., 14, 2019

人类盘状结构域受体2（Discoidin domain-containing receptor 2, DDR2）激酶与2-[4,5-二氟-2-氧代-1'-(1H-吡唑并[3,4-b]吡啶-5-羰基)螺[吲哚-3,4'-哌啶]-1-基]-N-(2,2,2-三氟乙基)乙酰胺的复合物晶体结构。配体描述：2-[4,5-二氟-2-氧代-1'-(1H-吡唑并[3,4-b]吡啶-5-羰基)螺[吲哚-3,4'-哌啶]-1-基]-N-(2,2,2-三氟乙基)乙酰胺。作者：Stihle, M、Richter, H、Benz, J、Kuhn, B、Rudolph, M.G.。存储日期：2018-01-03；发布日期：2018-11-28；最后修改日期：2024-05-01。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.87埃（Å）。引用文献：《基于DNA编码文库的DDR1抑制剂在Alport综合征遗传小鼠模型中预防纤维化及肾功能丧失》，发表于《ACS化学·生物学》（Acs Chem.Biol.），2019年，第14卷。