Mean values of different indirect effects, the total effect, and the percentages mediated for both standard regression and our approach.*

DOM: dominant genetic model; ADD: additive genetic model; REC: recessive genetic model*Includes the indirect effect through M1 (i.e., IE1 = a1b1), the indirect effect through M2 (i.e., IE2 = a2b2), the three-path indirect effect through M1 and M2 (i.e., IE3 = a1db2), the total indirect effect (i.e., IEt = IE1+IE2+IE3), the total effect (i.e., TE = IEt+c′), and the percentages of the SNP-disease association explained by different paths (i.e., PM1 = IE1/TE, PM2 = IE2/TE, PM3 = IE3/TE, and PMt = IEt/TE). All results are based on 1,000 replicates, each with 1,000 disease cases and 1,000 disease controls.