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Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97

NIAID Data Ecosystem2026-05-02 收录

疟原虫靶点结构

抗疟药物研发

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Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97

应用场景：

创建时间：

2024-07-31

抗疟疾药物研发

疟原虫靶点结构

To discover new antimalarial chemotypes, we screened the Janssen Jumpstarter library against the P. falciparum asexual parasite and identified the 7-N-substituted-3-oxadiazole quinolone hit class. We

NIAID Data Ecosystem30

Su, A. Synthesis of Antimalarial Compounds from the Triazolopyrazine Ether Series

抗疟药物研发

药物化合物

Alexander Su, Open Souce Malaria paper 2015

Figshare2016-01-20 更新10

Pyrimidine Azepine Targets the Plasmodium bc1 Complex and Displays Multistage Antimalarial Activity

抗疟药物研发

疟原虫靶点鉴定

Malaria control and elimination efforts would benefit from the identification and validation of new malaria chemotherapeutics. Recently, a transgenic Plasmodium berghei line was used to perform a seri

Figshare2024-10-07 更新00

β‑Hydroxy- and β‑Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth

抗疟药物研发

抗疟原虫活性筛选

Malaria is an infectious disease caused by a parasite of the genus Plasmodium, and the emergence of parasites resistant to all current antimalarial drugs highlights the urgency of having new classes o

NIAID Data Ecosystem30

Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein. null

抗疟药物研发

先导化合物

In a prior study, we identified the STAR-related lipid transfer protein (PfSTART1) as the molecular target of this antimalarial chemotype. In this study, we combined structural elements from the diffe

NIAID Data Ecosystem00

Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97

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