Inhibitor potencies on mouse heart AC and on AC1, 2 and 5.

IC50-values of putative AC5-selective inhibitors SQ22,536, NKY80 and vidarabine and of the reference inhibitor MANT-ITPγS on mouse heart AC from wild type (WT) or AC5 knockout mice (AC5KO) and on recombinant AC1, 2 and 5. IC50-values were calculated from concentration response curves demonstrated in Fig. 3 and 4 and are the means and the 95% confidence intervals (C.I.) of three independent experiments performed in duplicates. logIC50-values were compared against the logIC50 derived from mouse heart AC from AC5KOmice. Not significant (ns) = p>0.05,
*p<0.05,
**p<0.01,
***p<0.001,
****p<0.0001.