Cancer Therapeutics Response Portal

Cancer Therapeutics Response Portal (CTRP) 是一个癌症治疗反应数据库，链接了癌细胞系的遗传、谱系和其他细胞特征与小分子敏感性，旨在加速发现与患者匹配的癌症治疗方法。该数据库包含481种小分子化合物和860种深度表征的癌细胞系的敏感性数据，并提供了与突变、基因表达、拷贝数变异和谱系相关的分析。CTRP是一个面向生物医学研究社区的开放资源，可用于开发小分子作用机制见解和新的治疗假设。Cancer Therapeutics Response Portal (CTRP) is a cancer therapeutic response database that links the genetic, cellular lineage, and other cellular characteristics of cancer cell lines to their sensitivity to small molecules, aiming to accelerate the discovery of patient-matched cancer therapies. This database contains sensitivity profiling data across 860 deeply characterized cancer cell lines and 481 small molecule compounds, and provides analyses related to mutations, gene expression, copy number variations, and cellular lineages. CTRP is an open-access resource for the biomedical research community, enabling the development of mechanistic insights into small molecules and the generation of novel therapeutic hypotheses.