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Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

NIAID Data Ecosystem2026-03-10 收录

蛋白质错误折叠与ERAD降解

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数据链接：

https://www.omicsdi.org/dataset/bioimages/S-JCBD-201504109 数据链接链接失效反馈

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资源简介：

Immunostaining of mCD3-delta-deltaTM and its derivatives using anti-HA or anti-Sec61b antibody.

应用场景：

创建时间：

2018-11-29

内质网相关降解机制

蛋白质错误折叠清除

How misfolded proteins are exported from the ER to the cytosol for degradation (ER-associated Degradation, ERAD) and which proteins are participating in this process is not understood. Several studies

Figshare2016-01-18 更新40

Enterovirus 71 protease 2A pro and 3C pro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication

病毒-宿主相互作用

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Endoplasmic reticulum-associated degradation (ERAD) is an important function for cellular homeostasis. The mechanism of how picornavirus infection interferes with ERAD remains unclear. In this study,

NIAID Data Ecosystem20

Sel1L is Indispensable for Mammalian ERAD, ER Homeostasis and Survival. Mus musculus

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基因敲除小鼠

Sel1L is an adaptor protein for the E3 ligase Hrd1 involved in endoplasmic reticulum-associated degradation (ERAD). Its physiological importance in mammalian ERAD, however, remains to be established.

NIAID Data Ecosystem20

Organizational Diversity among Distinct Glycoprotein Endoplasmic Reticulum-associated Degradation Programs

蛋白质质量控制

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Protein folding and quality control in the early secretory pathway function as posttranslational checkpoints in eukaryote gene expression. Herein, an aberrant form of the hepatic secretory protein α1-

PubMed Central30

Oligosaccharyltransferase is involved in targeting to ER-associated degradation

蛋白质质量控制

内质网相关降解机制

The majority of secretory proteins undergo N-glycosylation, a process catalyzed by oligosaccharyltransferase (OST), a membrane-bound protein complex that associates with the translocation channels wit

NIAID Data Ecosystem20

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

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