Adult cardiac parameters measured by micro-ultrasound echocardiography.

Mean ± SE, N is shown in parentheses in column heading or in cell if different, missing N was due to fusion of E and A waves (indicated by #) or for other technical reasons.
***P<0.001,
**P<0.01,
*P<0.05 vs. WT; results were compared with age-matched WT mice with same background (usually littermates).
WT, wild type; Het, heterozygous; Homo, homozygous.
BW, body weight; HR, heart rate; PV-Ao, peak velocity in ascending aorta; CO, cardiac output; LV, left ventricle; ESV, end-systolic volume; EDV, end-diastolic volume; EF, ejection fraction; LVWAd, left ventricular wall anterior dimension; LVWPd, left ventricular wall posterior dimension; E-wave, early ventricular filling velocity; A-wave, ventricular filling velocity during atrial contraction; E/A, E-wave to A-wave ratio; ICT, isovolumetric contraction time; IRT, isovolumetric relaxation time; ET, ejection time; Tei Index, myocardial performance index = (ICT + IRT)/ET; LA area, left atrial area; PV-PA, peak velocity pulmonary artery; RV, right ventricle; RA area, right atrial area.