Are Periocular and Systemic Allergy Conditions Risk Factors for Pterygium?

To evaluate risk factors for pterygium and prevalence of periocular and systemic diseases among patients with pterygium. A retrospective case-control study was conducted among members of Clalit Health Services (CHS) in Israel, from 2001 to 2022. A total of 13,944 patients diagnosed with pterygium were included. For each case, three controls were matched among all CHS patients according to year of birth, sex, and ethnicity. Mixed models were used to assess differences in demographic characteristics, ocular and systemic diseases between the groups. Generalized estimating equation (GEE) logistic regression was used to estimate the odds ratios (OR) and adjust for confounders. The average age of pterygium patients was 49 ± 17 years; 51% were male. The results showed significant associations between pterygium and risk factors of vernal kerato-conjunctivitis (OR 2.52, 95% confidence interval [CI]: [1.96–3.24]), chronic allergic conjunctivitis (OR 1.98, 95% CI: [1.65–2.39]), blepharitis (OR 1.91, 95% CI: [1.78–2.04]), chalazion (OR 1.47, 95% CI: [1.30–1.67]) and unspecified systemic allergy (OR 1.21, 95% CI [1.09–1.34]), after adjusting for rural residency status. Glaucoma (OR 0.74, 95% CI [0.64–0.85]) and smoking (OR 0.70, 95% CI [0.66–0.75]) were protective factors against pterygium. Systemic and periocular inflammatory and allergic diseases are risk factors for pterygium.