Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin

Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin Descriptor: Aminoglycoside N(6')-acetyltransferase type 1, CHLORIDE ION, POTASSIUM ION, ... Authors: Stogios, P.J, Evdokimova, E, Minasov, G, Yim, V, Courvalin, P, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2012-04-26 Release date: 2012-05-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.768 Å) Cite: Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes. ACS Infect Dis., 3, 2017

溶血不动杆菌（Acinetobacter haemolyticus）来源的氨基糖苷类抗生素6'-N-乙酰转移酶AAC(6')-Ig与妥布霉素（tobramycin）形成复合物的晶体结构
描述符：氨基糖苷N(6')-乙酰转移酶1型（Aminoglycoside N(6')-acetyltransferase type 1）、氯离子（CHLORIDE ION）、钾离子（POTASSIUM ION）等
作者：Stogios P.J.、Evdokimova E、Minasov G、Yim V、Courvalin P、Savchenko A、Anderson W.F.、传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）
提交日期：2012-04-26
发布日期：2012-05-09
最后修改日期：2023-09-13
研究方法：X射线衍射（X-RAY DIFFRACTION），解析分辨率为1.768埃（Å）
引用文献：《不动杆菌属氨基糖苷乙酰转移酶的结构与生化表征：揭示抗生素抗性酶的功能与进化差异》，发表于《ACS感染性疾病》2017年第3卷