Structural Mapping of Amyloidogenic and Neurodegenerative Disease Targets — Neuro Research Dataset v1.0
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Abstract This dataset contains structural sequences, disorder annotations, and disease associations for 12 primary neurodegenerative disease targets. Included proteins span the major neurodegenerative pathologies: Alpha-synuclein and PINK1/Parkin/LRRK2 (Parkinson's disease), Tau and Amyloid-beta 42 (Alzheimer's disease), Huntingtin (Huntington's disease), TDP-43, FUS, and SOD1 (Amyotrophic Lateral Sclerosis), Prion protein (transmissible spongiform encephalopathies), Amylin/IAPP (Type 2 diabetes-associated amyloidosis), and CREB1 (neuroplasticity). Each entry includes UniProt accessions, DisProt disorder identifiers where available, and full-length amino acid sequences. This resource supports computational studies of protein aggregation, fibril nucleation, and the rational design of aggregation inhibitors. Plain Language Summary Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and ALS are characterized by the abnormal clumping of specific proteins in the brain, which damages and kills nerve cells. This dataset provides the complete molecular sequences of 12 key proteins involved in these diseases. By making this data openly available, we enable researchers to study exactly how and why these proteins misfold and aggregate, which is an essential step toward developing drugs that can prevent or reverse the protein clumping that drives neurodegeneration. Related Resources Source Code: GitHub — Nexus Resonance Codex / Protein-Folding Author Profile: ORCID — James Paul Trageser Author: @jtrag on X
摘要 本数据集收录了12种主要神经退行性疾病靶点的结构序列、无序区域注释及疾病关联信息。所覆盖的蛋白涵盖了主流神经退行性疾病的病理相关靶点：α-突触核蛋白（Alpha-synuclein）与PINK1/Parkin/LRRK2（关联帕金森病）、Tau蛋白及β淀粉样蛋白42（Amyloid-beta 42，关联阿尔茨海默病）、亨廷顿蛋白（Huntingtin，关联亨廷顿病）、TDP-43、FUS与SOD1（关联肌萎缩侧索硬化）、朊蛋白（Prion protein，关联传染性海绵状脑病）、胰岛淀粉样多肽（Amylin/IAPP，关联2型糖尿病相关淀粉样变性），以及环腺苷酸应答元件结合蛋白1（CREB1，关联神经可塑性）。每条数据条目均包含通用蛋白质知识库（UniProt）登录号，若有则提供蛋白质无序区域数据库（DisProt）的无序区域标识符，以及全长氨基酸序列。本资源可支撑蛋白质聚集、原纤维成核及聚集抑制剂理性设计等计算研究。 通俗语言概要 阿尔茨海默病、帕金森病、亨廷顿病及肌萎缩侧索硬化等神经退行性疾病，以大脑内特定蛋白质发生异常聚集为核心病理特征，该过程会损伤并杀死神经元。本数据集提供了上述疾病中12种关键蛋白的完整分子序列。通过公开该数据集，我们可为研究人员探究这些蛋白质错误折叠与聚集的具体机制与诱因提供支持，而这正是开发能够预防或逆转驱动神经退行性病变的蛋白质聚集的药物的关键前置步骤。 相关资源 源代码：GitHub — Nexus Resonance Codex / Protein-Folding 作者简介：ORCID — James Paul Trageser 作者：X平台@jtrag
