AutDB

AutDB is a deeply annotated resource for exploring the impact of genetic variations associated with autism spectrum disorders (ASD). First released in 2007, AutDB has evolved into a multi-modular resource of diverse types of genetic and functional evidence related to ASD. Current modules include: Human Gene, which annotates all ASD-linked genes and their variants; Animal Model, which catalogs behavioral, anatomical and physiological data from rodent models of ASD; Protein Interaction (PIN), which builds interactomes from direct relationships of protein products of ASD genes; and Copy Number Variant (CNV), which catalogs deletions and duplications of chromosomal loci identified in ASD.

AutDB是一款深度注释型资源，旨在探究与孤独症谱系障碍（Autism Spectrum Disorders，ASD）相关的遗传变异的影响。该资源于2007年首次发布，现已演进为涵盖孤独症谱系障碍相关多类遗传与功能证据的多模块资源。当前包含以下模块：
人类基因模块：对所有孤独症谱系障碍关联基因及其变异进行注释；
动物模型模块：收录孤独症谱系障碍啮齿类动物模型的行为学、解剖学及生理学数据；
蛋白质相互作用（Protein Interaction，PIN）模块：基于孤独症谱系障碍相关基因的蛋白质产物的直接相互作用关系构建相互作用组；
拷贝数变异（Copy Number Variant，CNV）模块：收录在孤独症谱系障碍患者中鉴定出的染色体位点缺失与重复变异数据。

搜集汇总

背景与挑战

背景概述

AutDB是一个自闭症研究专用数据库，涵盖1502个基因、2274个CNV、38296个蛋白质相互作用和3798个动物模型数据，为自闭症研究提供全面的模块化数据支持。