Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin [RNA-Seq]

This study aimed to characterize transcriptomic alterations in murine aortic valves following conditional deletion of Hdac3 in valvular interstitial cells. By comparing gene expression profiles between control and Hdac3-deficient valves, we aimed to identify molecular pathways regulated by HDAC3 that are crucial for maintaining aortic valve structure and function. These data provide insights into the epigenetic and metabolic mechanisms underlying non-calcific aortic valve disease. RNA seq on Aortic valves from 12-week-old control and Hdac3-knockout mice