Raw data of gut microbiota, blood metabolome and feces metabolome

In this study, we evaluated the potential of semaglutide to alleviate Diabetes-associated cognitive decline（DACD） in mice with DM. Eight-week-old mice fed a high-fat diet with streptozotocin-induced DM were subcutaneously injected with semaglutide (30 nmol/kg qd) for 12 weeks. Semaglutide treatment increased the relative abundances of g_Alistipes, g_norank_f_Eubacterium_coprostanoligenes, g-_Bacteroides, and g_Parabacteroides, while decreasing the relative abundances of g_ faecalibaculum, g_Colodertribacter, g_GCA-900066575, g_Erysipelatoclostridium, and g_norank_f_Lachnospiraceae. Semaglutide also induced alterations in fecal and serum metabolites, as well as transcriptomic changes in brain tissue, with significant common enrichment in neuroactive ligand-receptor interactions. Furthermore, strong correlations were observed among semaglutide-affected genes, metabolites, and microbiota, as assessed by correlation analysis and integrative modeling. In conclusion, these findings suggest that the protective effects of semaglutide against DACD are likely mediated through the microbiota-gut-brain axis. The data showed the raw data of blood metabolome,feces metabolome and gut microbiota.

本研究旨在评估西格鲁肽缓解糖尿病相关认知衰退（DACD）在小鼠模型中的潜力。实验中，对8周龄的以高脂饮食喂养并经链脲佐菌素诱导糖尿病的小鼠进行皮下注射西格鲁肽（30 nmol/kg qd），持续12周。西格鲁肽治疗显著提升了 g_Alistipes、g_norank_f_Eubacterium_coprostanoligenes、g-_Bacteroides 和 g_Parabacteroides 的相对丰度，同时降低了 g_ faecalibaculum、g_Colodertribacter、g_GCA-900066575、g_Erysipelatoclostridium 和 g_norank_f_Lachnospiraceae 的相对丰度。此外，西格鲁肽还引发了粪便和血清代谢物的变化，以及脑组织转录组的变化，其中神经活性配体-受体相互作用具有显著的共同富集。进一步地，通过相关性分析和整合建模，观察到西格鲁肽影响基因、代谢物和微生物群之间存在显著相关性。综上所述，这些发现表明西格鲁肽对DACD的保护作用可能通过微生物群-肠道-大脑轴介导。数据展示了血液代谢组、粪便代谢组和肠道微生物群的原始数据。