Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort

Human cytomegalovirus (HCMV) infection has been associated with increased mortality, specifically cardiovascular disease (CVD), in high-income countries (HICs). There is a paucity of data in low- and middle-income countries (LMICs) where HCMV seropositivity is higher.
Serum samples from 2,174 Ugandan individuals were investigated for HCMV antibodies and data linked to demographic information, co-infections and a variety of CVD measurements. HCMV seropositivity was 83% by one year of age, increasing to 95% by five years. Female sex, HIV positivity and active pulmonary tuberculosis (TB) were associated with an increase in HCMV IgG levels in adjusted analyses. There was no evidence of any associations with risk factors for CVD after adjusting for age and sex. HCMV infection is ubiquitous in this rural Ugandan cohort from a young age. The association between TB disease and high HCMV IgG levels merits further research. Known CVD risk factors do not appear to be associated with higher HCMV ...

人类巨细胞病毒（Human cytomegalovirus, HCMV）感染与高收入国家（high-income countries, HICs）的死亡率升高显著相关，其中尤以心血管疾病（cardiovascular disease, CVD）相关死亡为突出。而在人类巨细胞病毒血清阳性率更高的中低收入国家（low- and middle-income countries, LMICs）中，相关研究数据仍较为匮乏。
本研究针对2174名乌干达个体的血清样本开展人类巨细胞病毒抗体检测，并将检测数据与受试者的人口学信息、合并感染情况及多项心血管疾病检测指标进行关联分析。结果显示，该队列中人类巨细胞病毒血清阳性率在1岁时即达83%，至5岁时进一步升至95%。经多因素校正分析表明，女性性别、HIV阳性以及活动性肺结核（tuberculosis, TB）均与人类巨细胞病毒IgG抗体水平升高显著相关。在对年龄与性别进行校正后，未发现人类巨细胞病毒感染与心血管疾病危险因素存在任何关联的证据。从早年起，人类巨细胞病毒感染在这支乌干达农村队列中便已广泛流行。肺结核与高滴度人类巨细胞病毒IgG抗体之间的关联值得开展进一步研究。目前已知的心血管疾病危险因素似乎与更高水平的人类巨细胞病毒[原文未完整表述]无显著关联。