Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS10
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Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS10 Descriptor: 2-[(2,4-dihydroxyphenyl)sulfonyl]-2,3-dihydro-1H-isoindole-4,6-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... Authors: Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. Deposit date: 2013-09-13 Release date: 2014-01-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.752 Å) Cite: Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. J.Biol.Chem., 289, 2014
与抑制剂PS10结合的丙酮酸脱氢酶激酶同工酶2（pyruvate dehydrogenase kinase isoform 2）的晶体结构
组分描述：2-[(2,4-二羟基苯基)磺酰基]-2,3-二氢-1H-异吲哚-4,6-二醇、L(+)-酒石酸、[丙酮酸脱氢酶（硫辛酰胺）]激酶同工酶2……
作者：Gui, W.J、Tso, S.C、Chuang, J.L、Wu, C.Y、Qi, X、Tambar, U.K、Wynn, R.M、Chuang, D.T
提交日期：2013-09-13
发布日期：2014-01-01
最后修改时间：2024-02-28
实验方法：X射线衍射（分辨率1.752埃）
引用文献：《靶向ATP结合口袋的特异性丙酮酸脱氢酶激酶抑制剂的结构导向开发》，《生物化学杂志》，289卷，2014年
创建时间：
2013-09-13
