Primary human hepatocyte transcriptomic statin response

We have previously identified a number of statin-responsive genes in human cell lines, but in some cases, these findings may not be relevant in vivo. Here, we statin exposed primary human hepatocytes from four different donors to identify statin-responsive genes in this biologically relevant cell type. We also compared the effects of statin on gene expression between these primary cells and our previous datasets in other cell lines to identify overlapping effects of interest. Overall design: Primary human hepatocytes from 4 different donors treated with 0 nM, 500 nM or 2000 nM activated simvastatin