Frequency of exposed to medicines during the first trimester of pregnancy in 58,514 subjects with single or multiple birth defects (excluding minor anomalies and syndromes) and 110,814 non-malformed newborns.

References: (1): Prenatal medication exposure during the first trimester of pregnancy according to maternal report; (2): Exposed to the study medication, alone or in combination with other medications; (ATC code) Anatomical Therapeutic Chemical classification system.