Subcommissural organ (SCO) contributes to brain development via SCO-secreted peptides

To explore the role of SCO and its functional mechanism, we performed RNAseq between SCO and hippocampus at different stage to identify the expression of some unique genes and possible pathway related to the function of SCO. We cofirmed the role of SCO in neuronal development and identified three SCO-derived peptides which can contributed to neurite development and neuronal survival . Overall design: Differential expression analysis and Gene Set Enrichment Analysis of RNA seq data. We performed differential expression analysis of RNA seq data obtained from SCO and hippocampus of adult mice and Gene Set Enrichment Analysis obtained from SCO and hippocampus of P0 mice.