Early Plasma Exchange for SFTS-Associated Encephalopathy and MODS: A Case Report (PRJCA044111)

We report a rare case of SFTS in a 72-year-old woman who developed acute encephalopathy and multi-organ dysfunction shortly after a wasp sting. The patient presented with thrombocytopenia, elevated liver enzymes, and central nervous system involvement, including seizures and coma. Next-generation sequencing and serological testing confirmed SFTS. Despite standard antiviral and supportive therapies, rapid deterioration prompted therapeutic plasma exchange (TPE) initiation. After two sessions of TPE, the patient showed significant clinical improvement, including recovery of consciousness, normalization of laboratory markers, and resolution of neurological symptoms.