ARMS-mediated activation

ARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which is involved in the activation of Rap1 and the subsequent prolonged activation of the MAPK cascade.

ARMS（Ankyrin-Rich Membrane Spanning/Kidins 220）是一种分子量为220kD的四跨膜适配蛋白，其可被活化的Trk受体迅速进行酪氨酸磷酸化。ARMS作为一种适配蛋白，参与了Rap1的激活及其随后的MAPK级联反应的持续激活。