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A Highly Conjugated Dihydroxylated C28 Steroid from a Myxobacterium

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Figshare2016-02-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/A_Highly_Conjugated_Dihydroxylated_C_sub_28_sub_Steroid_from_a_Myxobacterium/2647411
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In the course of our search for novel secondary metabolites, the CHCl3–MeOH extract of the novel myxobacterial strain Sorangiineae SBNa008 was shown to be active against human SW480 colon adinocarcinoma cells. Bioassay-guided fractionation of the extract yielded a highly conjugated novel, sterol 9α,11α-dihydroxyergosta-4,6,8(14),22-tetraen-3-one, 1. The structure and the relative stereochemistry of 1 were established from interpretation of spectroscopic data and X-ray crystallography.
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2016-02-23
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