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Total Synthesis of Plukenetione A

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NIAID Data Ecosystem2026-03-06 收录
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We describe an alkylative dearomatization/acid-mediated adamantane annulation sequence that allows facile access to type A polyprenylated acylphloroglucinol natural products including plukenetione A. Introduction of the 2-methyl-1-propenyl moiety was achieved via stereodivergent SN2 and SN1 cyclizations of allylic alcohol substrates.

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2010-10-13
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