Dupilumab and Alopecia Areata

Some providers have used dupilumab off-label for the treatment of recalcitrant alopecia areata, particularly in patients with atopic dermatitis. However, many clinicians have noted mixed results, with some patients reporting improvement while other patients experiencing new-onset or worsening alopecia areata. The purpose of this systematic review was to investigate the clinical characteristics and outcomes in cases of dupilumab-treated and dupilumab-induced alopecia areata.

部分临床医师已超说明书使用度普利尤单抗（dupilumab）治疗难治性斑秃（alopecia areata），尤其针对伴特应性皮炎（atopic dermatitis）的患者。然而诸多临床医师均观察到疗效不一的情况：部分患者症状有所改善，而另有患者出现新发斑秃或原有斑秃病情加重。本项系统综述旨在探讨接受度普利尤单抗治疗以及由度普利尤单抗诱发的斑秃病例的临床特征与转归。