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Waveguide lattices offer a compact and stable platform for a range of applications, including quantum walks, topological effects, condensed matter system simulation, and classical and quantum information processing. In such lattices, the Hamiltonian's hopping and on-site terms determine the optical evolution, which can be engineered using waveguide spacing and refractive index profile. While waveguide lattices have been realized in various photonic platforms, these devices have always been static and designed for specific applications. We present a programmable waveguide array in which the Hamiltonian terms can be electro-optically tuned to implement various Hamiltonian continuous-time evolutions on a single device. We used a single array with 11 waveguides in lithium niobate, controlled via 22 electrodes, to perform a range of experiments that realized the Su-Schriffer-Heeger model, the Aubrey-Andre model, and Anderson localization, which is equivalent to over 2500 static devices. Our architecture's micron-scale local electric fields independently control waveguide coupling coefficients and effective indices, which overcomes cross-talk limitations of thermo-optic phase shifters in other platforms such as silicon, silicon-nitride, and silica. Electro-optic control allows for ultra-fast and more precise reconfigurability with lower power consumption, and with quantum input states, our platform can enable the study of multiple condensed matter quantum dynamics with a single device.