Biological functions of genes surrounding the 603 top associated SNPs. Results from GeneTrail.

A total of 823 genes surrounding the 603 top associated SNPs were put into the GeneTrail software. Surrounding genes were defined by either Grail (http://www.broadinstitute.org/mpg/grail/) or the Genome Browser (http://genome.ucsc.edu/). Gene families located in the same region were manually curated so that only one gene in each family remained in each region, based on a similar official gene symbol.
*Significant after multiple testing correction using FDR adjustment. (pcorr-value=0.032) Size of test set: 823 (768 known). Number of known ref. IDs: 44829 Kegg: Number of annotated genes in test set was 220. Number of annotated genes in ref set was 5405. Gene Ontology: Number of annotated genes in test set was 476. Number of annotated genes in ref set was 11580.
NIA human genes sets: Number of annotated genes in test set was 76. Number of annotated genes in ref set was 1487