Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs

Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs Descriptor: 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, ... Authors: Sharp, S.Y, Prodromou, C, Boxall, K, Powers, M.V, Holmes, J.L, Box, G, Matthews, T.P, Cheung, K.M, Kalusa, A, James, K, Hayes, A, Hardcastle, A, Dymock, B, Brough, P.A, Barril, X, Cansfield, J.E, Wright, L.M, Surgenor, A, Foloppe, N, Aherne, W, Pearl, L, Jones, K, McDonald, E, Raynaud, F, Eccles, S, Drysdale, M, Workman, P. Deposit date: 2007-03-20 Release date: 2007-04-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol. Cancer Ther., 6, 2007

新型合成强效间苯二酚基吡唑/异恶唑酰胺类化合物对热休克蛋白90（HSP90）分子伴侣的体外与体内抑制活性
描述物：5-(5-氯-2,4-二羟基苯基)-N-乙基-4-(4-甲氧基苯基)异恶唑-3-甲酰胺、热休克蛋白HSP 90-α、镁离子……
作者：Sharp, S.Y.、Prodromou, C.、Boxall, K.、Powers, M.V.、Holmes, J.L.、Box, G.、Matthews, T.P.、Cheung, K.M.、Kalusa, A.、James, K.、Hayes, A.、Hardcastle, A.、Dymock, B.、Brough, P.A.、Barril, X.、Cansfield, J.E.、Wright, L.M.、Surgenor, A.、Foloppe, N.、Aherne, W.、Pearl, L.、Jones, K.、McDonald, E.、Raynaud, F.、Eccles, S.、Drysdale, M.、Workman, P.
存档日期：2007-03-20
发布日期：2007-04-24
最后修改日期：2023-12-13
检测方法：X射线衍射（1.9 Å）
引用文献：新型合成强效间苯二酚基吡唑/异恶唑酰胺类化合物对热休克蛋白90分子伴侣的体外与体内抑制活性. 《分子癌症治疗》（Mol. Cancer Ther.），第6卷，2007年