Dataset related to article "Work Ability Assessment and Its Relationship with Cardiovascular Autonomic Profile in Postural Orthostatic Tachycardia Syndrome"

This record contains raw data related to article “ Work Ability Assessment and Its Relationship with Cardiovascular Autonomic Profile in Postural Orthostatic Tachycardia Syndrom" Postural orthostatic tachycardia syndrome (POTS) negatively impacts quality of life. The excessive increase in cardiac sympathetic modulation during standing, which characterizes POTS patients, leads to many symptoms and signs of orthostatic intolerance. Little is known about the consequences of the disease on work performance and its relationship with individual autonomic profiles. Twenty-two POTS patients regularly engaged in working activity (20 females, age 36 ± 12 years) and 18 gender- and age-matched controls underwent a clinical evaluation and filled out the Work Ability Index (WAI) questionnaire. POTS patients completed the Composite Autonomic Symptom Score (COMPASS31) questionnaire, underwent continuous electrocardiogram, blood pressure and respiratory activity recordings while supine and during a 75° head-up tilt (HUT). A power spectrum analysis provided the index of cardiac sympatho-vagal balance (LF/HF). WAI scores were significantly reduced in POTS patients (29.84 ± 1.40) compared to controls (45.63 ± 0.53, p &lt; 0.01). A significant inverse correlation was found between individual WAI and COMPASS31 scores (r = -0.46; p = 0.03), HUT increase in heart rate (r = -0.57; p = 0.01) and LF/HF (r = -0.55; p = 0.01). In POTS patients, the WAI scores were inversely correlated to the intensity of autonomic symptoms and to the excessive cardiac sympathetic activation induced by the gravitational stimulus.本数据集包含与论文《体位性直立性心动过速综合征患者的工作能力评估及其与心血管自主神经特征的关联》相关的原始数据。体位性直立性心动过速综合征（Postural Orthostatic Tachycardia Syndrome, POTS）会对患者的生活质量造成负面影响。POTS患者的特征为站立时心脏交感调节过度增强，进而引发诸多直立不耐受相关症状与体征。目前学界对该疾病对工作表现的影响，以及其与个体自主神经特征的关联所知甚少。本研究纳入22名规律参与工作的POTS患者（20名女性，年龄36±12岁），以及18名性别与年龄匹配的健康对照者，所有受试者均接受临床评估并填写工作能力指数（Work Ability Index, WAI）问卷。POTS患者还完成了复合自主神经症状评分（Composite Autonomic Symptom Score, COMPASS31）问卷，并在仰卧位及75°头高位倾斜试验（Head-up Tilt, HUT）过程中接受持续心电图、血压及呼吸活动记录。通过功率谱分析计算得到心脏交感-迷走平衡指标（低频/高频功率比值，LF/HF）。结果显示，POTS患者的WAI评分（29.84±1.40）显著低于对照组（45.63±0.53，p<0.01）。个体WAI评分与COMPASS31评分（r=-0.46；p=0.03）、头高位倾斜试验中的心率增幅（r=-0.57；p=0.01）以及LF/HF值（r=-0.55；p=0.01）均存在显著负相关关系。在POTS患者中，WAI评分与自主神经症状严重程度及重力刺激诱导的过度心脏交感激活呈负相关。