ICOSLG is associated to anti-PD1 and concomitant antihistamine treatment response in advanced melanoma

NIAID Data Ecosystem2026-05-02 收录

黑色素瘤免疫治疗

ICOSLG基因关联

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https://zenodo.org/record/13838852 数据链接链接失效反馈

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Dataset of manuscript: ICOSLG is associated to anti-PD1 and concomitant antihistamine treatment response in advanced melanoma

创建时间：

2024-10-31

Force expression LNK suppresses interferon Gamma signaling

黑色素瘤免疫治疗

JAK-STAT信号通路调控

LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma;

NIAID Data Ecosystem30

Cell populations and clinical information for 177 melanoma samples.

黑色素瘤免疫治疗

流式细胞术

A training set of 110 patients and a validation set of 41 samples with advanced melanoma. Note that some samples were measured in duplicates. Whole blood was collected from healthy thrombocyte donors.

Figshare2024-04-18 更新20

A Randomized, Placebo-Controlled Phase III Trial of Yeast Derived GM-CSF Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients With "No Evidence of Disease" After Complete Surgical Resection of "Locally Advanced" and/or Stage IV Melanoma

黑色素瘤免疫治疗

GM-CSF

This randomized phase III trial studies sargramostim (Granulocyte-macrophage colony-stimulating factor, GM-CSF) or vaccine therapy alone to see how well they work compared to sargramostim and vaccine

DataCite Commons2025-06-01 更新10

Gut microbiome impacts response to PD-1 immunotherapy in melanoma patients

肠道微生物组与免疫疗法响应

黑色素瘤免疫治疗

Pre-clinical mouse models have suggested that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy, however this has not been well-characterized in human cancer patients. H

NIAID Data Ecosystem30

Vaccination and topical imiquimod treatment promote immune signatures in melanoma. Homo sapiens

黑色素瘤免疫治疗

肿瘤微环境

Introduction: Infiltration of cancers by T-cells is associated with improved patient survival and response to immune therapies; however, optimal approaches to induce T-cell infiltration of tumors are

NIAID Data Ecosystem20

ICOSLG is associated to anti-PD1 and concomitant antihistamine treatment response in advanced melanoma

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