Tumor microenvironment comprises of a variety of cell types, which is quite complex and involved in chemotherapy and immune checkpoint blockage resistance. In order to explore the mechanisms involved

NIAID Data Ecosystem50

Table_1_Relevance of Immune Infiltration and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma Subtypes.xlsx

胰腺癌免疫微环境

免疫治疗生物标志物

PurposePancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with high heterogeneity and dismal survival rates. Tumor immune microenvironment plays a critical role in sensitive to chemotherapy an

NIAID Data Ecosystem30

A Major Chromatin Regulator Determines Resistance of Tumor Cells to T cell Mediated Killing

肿瘤免疫逃逸

肿瘤免疫治疗抵抗

Many human cancers are resistant to immunotherapy for reasons that are poorly understood. We used a genome-scale CRISPR/Cas9 screen to identify mechanisms of tumor cell resistance to killing by cytot

NIAID Data Ecosystem50

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

胰腺癌免疫微环境

HIF-2α靶向治疗

Background & Aims. Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma, which contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible f

NIAID Data Ecosystem40

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma impair CD8+ T cell activation and responsiveness to immunotherapy in mice

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