H3K36me3 protects the mouse epigenome from single nucleotide variations
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We adopt histone H3 mutants competitive incorporation system to screen the effects of them on genetic fidelity. We find incorporation of H3K36M, an oncogenic histone mutant, produce a cancer or ageing-like genetic landscape by punctuating the H3K36me3/H3K9me3 dependent DNA repair mechanism. This work firstly get a direct relationship between epigenetic inheritance and genomic stability
创建时间：
2022-02-20
