Data and code for: Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.

This repository contains the data and code required to reproduce the figures and analyses in Ziehr et al., "Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis," Science Translational Medicine (2025). The repository is structured as an R project with a targets pipeline. All package dependencies are managed with renv. To reproduce the analyses, restore the package environment with renv::restore() and execute the pipeline with targets::tar_make(). Processed RNA-seq and spatial transcriptomics data objects are available as companion data packages at https://doi.org/10.5281/zenodo.19198539 and https://doi.org/10.5281/zenodo.19244873, respectively. Raw data underlying the pipeline outputs are deposited in NCBI SRA under BioProject PRJNA1011992 (RNA-seq) and NCBI GEO under accession GSE325253 (spatial transcriptomics).本仓库包含复现Ziehr等人2025年发表于《科学转化医学（Science Translational Medicine）》的论文《乳酸转运抑制在实验性肺纤维化中治疗性重编程成纤维细胞代谢》所需的数据与代码。 本仓库采用R项目结构，搭配targets工作流进行搭建。所有软件包依赖均通过renv工具进行管理。如需复现全部分析流程，请先执行`renv::restore()`恢复软件包运行环境，再通过`targets::tar_make()`运行整个工作流。经过处理的RNA测序（RNA-seq）与空间转录组学（spatial transcriptomics）数据对象可分别通过以下两个配套数据包获取：https://doi.org/10.5281/zenodo.19198539 与 https://doi.org/10.5281/zenodo.19244873。 本工作流输出结果所依赖的原始数据分别存储于：NCBI序列读取档案（NCBI SRA）的BioProject PRJNA1011992（对应RNA-seq数据），以及NCBI基因表达综合数据库（NCBI GEO）的登录号GSE325253（对应空间转录组学数据）。