Ultra-Rare Quartet Fracture Class and Unique Reference-Backed Displaced Appendage in a Computational Longevity Discovery Pipeline (Trinity Claims #60-#61, 2026-03-19)

This version fixes a new cohesive milestone from the Trinity longevity-discovery pipeline. Claim #60 shows that the strong tri-core plus partial-plus-veto outsider geometry is an ultra-rare quartet fracture class in the evaluable huMAP3 quartet universe: 9 of 1068 quartets. Claim #61 shows that only one of those rare fractures is reference-backed by both an exact same-core triad and a stable same-core replacement quartet: the TOP3A/RMI2/CCDC69/PITRM1 scaffold, with RMI1 as the stable replacement outsider. This version also includes a wet-lab differential falsification package centered on PITRM1 versus RMI1 with the TOP3A/RMI2/CCDC69 core held fixed. This is a computational discovery package and not a completed causal validation study.本版本修订了Trinity长寿发现流程（Trinity longevity-discovery pipeline）中的全新衔接性里程碑节点。断言60显示，带有强三核心搭配部分否决型外围组分结构构型的四重体(quartet)断裂类别，在可评估的huMAP3四重体总体中属于超稀有类型：1068个四重体中仅占9例。断言61显示，此类稀有断裂中仅有一例同时获得完全同源三核心复合体与稳定同源替换型四重体的参考佐证：即TOP3A/RMI2/CCDC69/PITRM1支架复合物，其外围替换组分为RMI1。本版本还纳入了以PITRM1与RMI1为对比对象、固定TOP3A/RMI2/CCDC69核心的湿实验(wet-lab)差异化证伪分析套件。该套件属于计算发现类工具包，尚未完成因果验证研究。