BindingDB Entry 50030934: Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.

Small molecule binding data for protein Aurora kinase B/Inner centromere protein, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Platelet-derived growth factor receptor beta, Serine/threonine-protein kinase Aurora, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O14965, P00533, P04626, P09619, P35916, P35968, Q02763, and Q96GD4

本数据集包含针对以下靶标蛋白的小分子结合数据：极光激酶B/着丝粒内蛋白（Aurora kinase B/Inner centromere protein）、表皮生长因子受体（Epidermal growth factor receptor）、表皮生长因子受体与ErbB2（HER1及HER2）、黏着斑激酶1/血管内皮生长因子受体3（Focal adhesion kinase 1/vascular endothelial growth factor receptor 3）、血小板衍生生长因子受体β（Platelet-derived growth factor receptor beta）、丝氨酸/苏氨酸蛋白激酶极光（Serine/threonine-protein kinase Aurora）、血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2），以及血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR及TIE2）；上述靶标对应的通用蛋白质资源数据库（Universal Protein Resource, UniProt）编号依次为O14965、P00533、P04626、P09619、P35916、P35968、Q02763及Q96GD4。