Characterisation data of common pharmaceutical excipient powders and tablets

Excipients are essential components within pharmaceutical formulations that are used to enhance properties such as the binding, disintegration, preservation, and patient friendliness of common dosage forms such as tablets, capsules, and inhalers. Common excipients such as micro-crystalline cellulose (MCC), dibasic calcium phosphate dihydrate (DCPD), and partially pre-gelatinised corn starch (PGS) therefore play a critical role in the design and production process of both new and old drug formulations. However, despite the importance of these powders, reference data is not publicly available. This is an extensive data set on MCC, DCPD, and PGS. This data set includes highly detailed information on individual grains, including particle sizes, crushing, and geometries. Using a compaction simulator, the powders and various mixtures thereof were compressed to make tablets, which were later subjected to a wide range of mechanical tests. This data set provides a reference point for the pharmaceutical industry, educators, and process developers alike.药用辅料（Excipient）是药物制剂的核心组成成分，用于优化片剂、胶囊剂、吸入剂等常用剂型的黏合性、崩解性、防腐性及患者友好性等性能。常见药用辅料如微晶纤维素（MCC）、磷酸氢钙二水合物（DCPD）及部分预糊化玉米淀粉（PGS），在新旧药物制剂的研发与生产全流程中均发挥关键作用。然而尽管这类粉体材料至关重要，其公开参考数据却长期缺失。本数据集针对微晶纤维素（MCC）、磷酸氢钙二水合物（DCPD）及部分预糊化玉米淀粉（PGS）构建，内容覆盖全面。数据集包含单颗粒的详尽信息，涵盖粒径、破碎特性与几何形貌等维度。研究采用压片模拟装置对上述粉体及其多种混合配比进行压片制样，随后对所得片剂开展多类力学性能测试。本数据集可为制药行业、教育工作者及工艺研发人员提供权威参考依据。