CRISPR-Cas genome-editing nucleases hold substantial promise for human therapeutics but identifying unwanted off-target mutations remains an important requirement for clinical translation. For ex vivo

NIAID Data Ecosystem40

High-throughput sequencing data of eeCas9 and eeBE of file6

基因编辑脱靶检测

碱基编辑器评估

Evaluation of the off-target efficiency of eeABEmax and ABEmax by HTS analysis in 293T cells.

NIAID Data Ecosystem60

Additional file 1 of The genomes of precision edited cloned calves show no evidence for off-target events or increased de novo mutagenesis

基因编辑脱靶检测

基因组编辑安全性评估

Additional file 1: Table S1 Predicted and candidate off-target mutations.

NIAID Data Ecosystem40

293T Raw sequence reads. Homo sapiens

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