Genomic profiling of gastric adenomas by array-based comparative genomic hybridization (CBX94). unidentified

To date, there are no reports showing the correlations between genomic copy number aberrations (CNAs) and histopathologic features of gastric adenoma. In this study, we investigated genomic CNAs of 20 adenomas including 7 low-grade adenomas (LGA; Vienna category 3) and 13 high-grade adenomas (HGA; Vienna category 4.1), by oligonucleotide-based array CGH. We found that the pattern of CNAs of HGA was quite different from those of LGA. The most frequent CNAs in HGA were gain at 8q (62%) and 7pq (54%), whereas those in LGA were gain at 7q21.3-q22.1 (57%) and loss at 5q (43%). Interestingly, gains at 8q and 7pq, both of which were most frequently occurred in HGA, were not detected in any cases of LGA. Of note, 8q gain was most frequently detected in both HGA and CIS but undetected in LGA. Since HGA has been believed to have a higher risk to progress into invasive carcinoma than LGA, our data suggest that 8q gain may play an important role in the malignant transformation of gastric adenoma.