A Biomimetic Synthesis Elucidates the Origin of Preuisolactone A
收藏NIAID Data Ecosystem2026-03-11 收录
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A short, biomimetic synthesis of the fungal metabolite preuisolactone A is described. Its key steps are a purpurogallin-type (5 + 2)-cycloaddition, followed by fragmentation, vinylogous aldol addition, oxidative lactonization, and a final benzilic acid rearrangement. Our work explains why preuisolactone A has been isolated as a racemate and suggests that the natural product is not a sesquiterpenoid but a phenolic polyketide.
创建时间：
2019-09-13
