Formal Total Synthesis of (−)-Apicularen A via Transannular Conjugate Addition
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The formal total synthesis of the myxobacteria metabolite (−)-apicularen A (1) is described. The key step involved a novel acid-mediated transannular conjugate addition of the C13 hydroxyl into the α,β-unsaturated ketone in either of the macrolactones 5a or 5b to provide the same trans-pyranone 4. Conversion of 4 into the known apicularen intermediate diol 3 completed the formal synthesis.
创建时间：
2004-04-15
