Expression profile of CircRNA in Type2 diabetes mellitus patients with retinopathy. Expression profile of CircRNA in Type2 diabetes mellitus patients with retinopathy

Diabetic retinopathy (DR) is one of the common chronic complications of diabetes. Circular RNA (circRNA) plays a vital role in the pathological process of diabetic retinopathy (DR), this study aims to explore the differences in circRNA expression profiles and functions between DR and non-DR patients.Serum from diabetes mellitus (DM) patients with DR (n=5) and without DR (n=5) were extracted for circRNA microarray analysis using Arraystar Human circRNA expression profile (v2.0). Another 5 DR and 5 non-DR patients were included for quantitative reverse transcription polymerase chain reaction (RT-qPCR) validation. Enriched signaling pathways were analyzed by GO and KEGG analysis. circRNA–miRNA networks were constructed by bioinformatics analysis. Overall design: This study aims to explore the differences in circRNA expression profiles and functions between DR and non-DR patients.