Christopher Woodcock (2011) CIL:122, Gallus gallus gallus, erythrocyte. CIL. Dataset

Telomeres isolated from chicken erythrocyte nuclei following restriction endonuclease treatment, and imaged by transmission EM after uranyl acetate negative staining. Sample was also labeled for the telomere protein TRF1 using immunogold.
Image recorded with FEI Tecnai 12 TEM at 100KV and recorded on 2048x2048 CCD with 2x binning.
Telomeres have a looped conformation, which likely aids in their protection from the rapid degradation that occurs with free DNA ends.

来自鸡红细胞核经过限制性内切酶处理的端粒，经铀酰乙酸负染色后，通过透射电子显微镜成像。样本同时进行了端粒蛋白TRF1的免疫金标记。图像由FEI Tecnai 12透射电子显微镜在100KV电压下拍摄，并使用2048x2048的CCD传感器以2倍合并记录。端粒呈现出环状结构，这有助于其抵御游离DNA末端发生的快速降解。