Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with biantennary pentasaccharide M592

Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with biantennary pentasaccharide M592 Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, ... Authors: Wu, L, Darby, J.F, Gilio, A.K, Davies, G.J. Deposit date: 2020-04-04 Release date: 2020-08-05 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V Acs Catalysis, 2020

MGAT5（α-1,6-甘露糖基糖蛋白6-β-N-乙酰葡糖胺转移酶V，alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V）管腔结构域的晶体结构，该结构带有Lys329-Ile345环截短，并与双天线五糖M592形成复合物。
组成描述：1,2-乙二醇、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1-2)-α-D-吡喃甘露糖-(1-3)-[2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1-2)-α-D-吡喃甘露糖-(1-6)]α-D-吡喃甘露糖……
作者：Wu L、Darby JF、Gilio AK、Davies GJ
存档日期：2020-04-04
发布日期：2020-08-05
最后修改日期：2024-11-20
实验方法：X射线衍射（分辨率1.6埃）
引用文献：《N-乙酰葡糖胺转移酶V的底物结合与催化机制》，ACS催化，2020年