THE BURDEN OF SYSTEMIC INFLAMMATION AND MULTIORGAN INVOLVEMENT IN ANKYLOSING SPONDYLITIS: CLINICAL PATTERNS AND THERAPEUTIC PERSPECTIVES

Ankylosing spondylitis (AS) is a prototypical form of axial spondyloarthritis characterized by chronic inflammation of the sacroiliac joints and spine, progressive structural damage, and functional impairment. Historically regarded as a disease confined to the axial skeleton, AS is now understood as a systemic inflammatory disorder with diverse clinical expressions.强直性脊柱炎（Ankylosing spondylitis, AS）是中轴型脊柱关节炎（axial spondyloarthritis）的典型代表，以骶髂关节与脊柱的慢性炎症、进行性结构损伤及功能障碍为特征。既往曾被认为是仅局限于中轴骨骼的疾病，如今则被认知为一类具有多样化临床表现的全身性炎症性病症。