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microRNA expression profiling of response to first-line aromatase inhibitor therapy

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78870
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The main goal of the study is to define miR expression levels related to clinical and biological parameters. Now in particular, miR expression levels of fresh frozen (estrogen receptor-positive) primary tumors were related to PIK3CA genotype and with progression-free survival in breast cancer patients with metastatic breast cancer that received first-line aromatase inhibitor therapy. Primary breast cancer specimens (N=106) were analyzed for the expression of 768 miRs. The miRs were normalized against the median level of 314 reference assays.
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2016-03-03
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