Development of New Calcium Channel Inhibitors for the Treatment of Neuropathic Pain

Neuropathic pain is a type of chronic pain that responds poorly to traditional pain therapies. We worked on developing new molecules capable of blocking calcium channels involved in the transmission of these pain signals. Advanced molecular modelling was used to aid in the design of these compounds; they were then produced using efficient and flexible synthetic routes. A series of highly promising drug candidates was thus discovered, with high activity against the target, low clearance in blood and metabolic stability assays, and well-balanced physicochemical properties.