Hereditary spastic paraplegias expanded network

HSP expanded network Starting with a seed list of 718 genes that are associated or causative of HSP according to OMIM, we built a protein interactome network based on the principle that physical and functional interacting proteins (to these 718 seed genes) could account for related biological processes and cause similar diseases. We developed a prioritization method that identifies the most likely disease-causing genes associated with each patient's phenotype (standardized in Human Phenotype Ontology (HPO)) using a global protein human interactome network built with functional and physical interactions, represented by 20.146 genes. We applied this prioritization tool to the respective clinical description in HPOs of the 718 proteins associated with HSP to build a HSP interactome or expanded network, resulting in 2187 proteins and 27759 interactions.