MetaDrugSig

MetaDrugSig is a transcriptomic drug signature database containing consensus gene expression signatures for 1,092 drugs, generated from 6,593 comparisons across 3,683 GEO series. Drug signatures were computed using restricted maximum likelihood (REML) random-effects meta-analysis for drugs with ≥2 independent studies (Tier 1) or edgeR differential expression for single-study drugs (Tier 2). The database covers 66,474 genes and includes per-gene uncertainty metrics (standard error, heterogeneity estimates) not available in existing resources.MetaDrugSig是一款转录组药物特征数据库，收录了1092种药物的共识基因表达特征，相关数据源自3683个GEO系列中的6593次对比实验。针对包含≥2项独立研究的药物（一级，Tier 1），其药物特征通过限制最大似然（restricted maximum likelihood, REML）随机效应元分析计算得到；而针对仅含单项研究的药物（二级，Tier 2），则采用edgeR差异表达分析进行计算。该数据库覆盖66474个基因，还包含了现有资源中未提供的单基因不确定性指标（标准误、异质性估计值）。